Western blotting, also known as immunoblotting, is a blotting technique that plays an essential role in separating and identifying proteins. The different steps in western blotting include tissue preparation, gel electrophoresis, transfer of proteins onto membrane, blocking to prevent membrane and antibody interactions, incubation of membrane, and antibody-based detection of proteins.
The global western blotting market, which previously accounted for US$ 605.7 million in terms of value, is now expected to reach US$ 993.4 million by the end of 2027.
The major players operating in the global western blotting market include Thermo Fisher Scientific, Inc., GE Healthcare, Hoffmann-La Roche Ltd., Danaher Corporation (Lumigen, Inc.), EMD Millipore Corporation, Bio-Rad Laboratories, Inc., PerkinElmer Inc., LI-COR, Inc., Bio-Techne Corporation (ProteinSimple Inc.), and Advansta, Inc.
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Increasing prevalence of HIV/AIDS is expected to boost the growth of the global western blotting market over the forecast period. According to the Joint United Nations Program on HIV/AIDS, around 37.9 million people around the globe were diagnosed with HIV in 2018.
Growing range of application of the western blotting technique is further anticipated to the global market expansion. For instance, in January 2020, researchers at the British Antarctic Survey, Natural Environment Research Council, U.K., reported the use of the western blotting procedure in the assessment of post-translationally deiminated protein and EV profiles of plasma in seabird species from the Antarctic region.
On the contrary, the emergence of various alternative technologies is foreseen to hamper the growth of the global market in the upcoming years. For instance, the AlphaScreen technology is an emerging, highly sensitive homogenous bead-based platform, which is used for the detection of biomolecules. This technique does not involve the cumbersome wash-steps and detects any molecule of interest, largely from protein complexes. Moreover, the western blotting technique is a semi-quantitative process and can provide only an approximate measurement. Such a drawback is also likely to hinder the global market growth.
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Introduction of better imaging software for management of western blotting results is expected to offer lucrative growth opportunities for players in the global western blotting market. Increasing use of western blotting results in generation of large amount of data, which needs to be stored, organized, and interpreted. Use of photo management software for scanning film-based results and creating albums will enable space saving, random access, result backup, and easy result sharing.
The key players in the global market are currently focusing on developing digital western blotting in order to enhance their market share. However, there is increasing use of the conventional western blotting systems, due to the high costs of the automated systems.
The product type segment in the global western blotting market was valued at US$ 605.7 million in 2018 and is expected to reach US$ 993.4 million by 2027, recording a CAGR of 5.4% during the forecast period.
The use of western blotting in R&D in cancer has significantly scaled up globally. For instance, in January 2020, researchers at The First Affiliated Hospital of Soochow University, China, reportedly used western blotting in the investigating the role of microRNA-708 (miR-708) in cervical cancer.
Furthermore, the global market is witnessing an increasing use of fluorescent western blotting in protein detection, as it generates lesser chemical waste and is a reliable method of collecting quantitative data. It can also be used to detect multiple proteins simultaneously.
Among regions, North America, followed by Europe, held a dominant position in the global western blotting market in 2018, accounting for a robust 34.4% market share, in terms of value.
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The key market players are highly focused on adopting M&A strategies to expand their product portfolio. For instance, in June 2019, Bio-Techne Corporation reached agreement to acquire B-MoGen Biotechnologies Inc. Furthermore, in November 2019, Bio-Rad Laboratories, Inc. launched EveryBlot Blocking Buffer, a western blot blocking reagent that offers 5-minute blocking time and produces higher signal and lower background levels.
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